抄録
When chlorpromazine is administered to women in both the early and the later stages of normal pregnancy, with toxemia of late pregnancy or in postclimacteric age, the excretion into urine of estrone, estradiol, estriol, pregnanediol and total 17-hydroxycorticoid was found reduced, but that of total 17-ketosteroid was little affected.
Following administration of chlorpromazine, the values not only of excreted pituitary but also of chorionic gonadotropin were decreased, the action of ACTH in stimulating the adrenal cortex was lowered and the response to Friedman's test was inhibited. Consequently, it is inferred that chlorpromazine, beside depressing the center of internal secretion, simultaneously reduces the function of the peripheral endocrine organs as well as of the placenta.
