抄録
The family history of diabetes in parents and siblings was analyzed in relation to the age of onset and previous obesity in patients with non-insulindependent diabetes mellitus (NIDDM). The frequency of a positive family history of diabetes in parents was higher in patients with the onset of diabetes earlier than 40 years of age than in those who developed diabetes after 50 years of age (32% vs 12%, p<0.001). The frequency of a positive family history in siblings was about 20% and fairly constant in patients who became diabetic after 30 years. The prevalence of diabetes in siblings was higher in patients with diabetic parents than in those without diabetic parents (p<0.001). The higher frequency of diabetes in parents of young-onset patients remained significant even in a comparison of patient groups of similar ages (50-59 years) at the interview. Patients with definite obesity in the past had a significantly lower frequency of family history of diabetes in parents (p<0.001), and a lower prevalence of diabetes in their parents (p<0.001) and siblings (p<0.05) than did patients without obesity. The frequency of patients who had diabetic siblings did not differ between obese and lean groups. These data suggest that implications of the presence of diabetes in parents and in siblings are different in family history studies. The higher frequency of a family history of diabetes in parents of young-onset and non-obese NIDDM patients may mean that exogenous diabetogenic factors such as obesity and aging are less important in the occurrence of diabetes in those who have diabetic parents than in those without diabetic parents.
