抄録
Alterations in catecholamine (CA) and thyroid hormone metabolism were examined in a 12-year-old girl with anorexia nervosa during 3 months of treatment. Accordingto her body weight change, the observation period was divided into 3 stages: initial emaciation (stage 1). stable maintenance of the -30% level of the previous weight (stage 2) and convalescent stage (stage 3). Stage 1 was characterized by relatively high urinary norepinephrine (NE) andepinephrine (E) but low dopamine (DA) excretion, elevated plasma DA-βAhydroxylase (DBH) activity and reduced serum thyroid hormones, especially the triiodothyronine (T3) level. In stage 2, urinary CAs were markedly suppressed, while serum thyroid hormones gradually increase. Instage 3, a great increase in DA excretion, a fall in plasma DBH activity and normalization of thyroid hormones were observed. In the low T3 state below 60ng/dl, urinary NE+E/DA ratios were elevated and widely fluctuated (0.58±0.30, SD), but were gradually decreased and completely stabilized in the normal T3 state (0.07±0.02, P<0.001). These results indicate that (1) although total CA production was depressed in anorexia nervosa, a change from an adrenergicdominantto a dopaminergic-dominant state occurs in accordance with body weight gain, and (2) this shift in the CA profile is associated with concomitantrecovery of reduced thyroid hormone concentrations. Thus, as for the energy expenditure, compensatory changes were observed in CAs and thyroid hormones in relation to caloric restriction.
