抄録
To evaluate the prevalence of hyperprolactinemia in patients with polycystic ovarian syndrome (PCO), 72 patients with oligo-or anovulation were studied. All of the patients had persisting elevated LH (>25mIU/ml), normal FSH, high LH/FSH ratio (>2.5), and exaggerated LH responses to LHRH. Mean testosterone and androstenedione concentrations were appreciably increased in these patients. Out of 171 samples for prolactin (PRL) determination from these 72 patients, only 5 patientshad a PRL value above 30ng/ml during the first sampling. The next sampling fromthese same 5 women disclosed that they were transiently hyperprolactinemicbecause the next samples showed a normal PRL value. To further investigate the PRL secretory capacity 500μg of TRH and 10mg of metoclopramide (MCP) were administered to these 72 and 44 patients, respectively. The PRL response to MCP was significantly blunted in these patients compared to normal women while the PRL response to TRH in these patients was not indistinguishable from that in normal women.These results indicate that the true prevalence rate of hyperprolactinemia inPCOmay be low rather than high and the association of hyperprolactinemia with PCO may be coincidental rather than a pathogenically related phenomenon.
