Endocrinologia Japonica
Online ISSN : 2185-6370
Print ISSN : 0013-7219
ISSN-L : 0013-7219
Generalized Resistance to Thyroid Hormone (GRTH) in a Family: Case Studies
KIYOSHI TANAKAAKIRA SUGAWARAMAKOTO SAKAMOTOTATSUHIDE INOUEAYUMI YAWATAOSAMU KOSHIMURAYOSHIYASU SAKOSHIGEKAZU SASAKIAKIRA SHIMATSUHIROTOSHI NAKAMURAHIROO IMURA
著者情報
キーワード: Thyroid hormone resistance
ジャーナル フリー

1992 年 39 巻 6 号 p. 533-538

詳細
抄録

A familial case of generalized resistance to thyroid hormone (GRTH) is described. A 17-year-old man (case 1), who had been treated with methimazole under the diagnosis of Graves' disease and his 11-year old sister (case 2) visited our clinic for the evaluation of their thyroid function. They lacked the signs and symptoms of thyrotoxicosis in spite of extremely high serum thyroid hormone levels. Their plasma TSH levels were not suppressed, but in fact markedly increased after TRH loading. Their peripheral indices of thyroid hormone were within normal limits and were not influenced by exogenous T3 administration. Even 150μg T3 administration for 7 days did not fully suppress the TRH-stimulated TSH level in case 2. The two patients thus were diagnosed to have GRTH. Sera from their father and another sister showed identical abnormalities.

著者関連情報
© The Japan Endocrine Society
前の記事 次の記事
feedback
Top