INDEPENDENCE OF THE GOITER DEVELOPMENT TO THE CONCENTRATION OF CIRCULATING PROTEIN BOUND IODINE

Abstract

It was observed that, in rats treated with M. T. U., the goiter occurs before any fall of P. B. I. occurs, then it declines conversely when P. B. I. concentration became significantly low. In addition it was observed that P. B. I. concentration in women with various durations and grades of simple goiter in the area of endemic goiter is, in all possibility, within normal range throughout the course of goiter development.
These facts indicate that the output of thyrotrophic hormone from the anterior pituitary is not always controlled by the level of circulating thyroid hormone and factors other than P. B. I., level would regulate the output of it.
The disturbance of hormone synthesis would be at first felt by hypothalamic cells, which soon give the stimulation via the portal vessel to the adenohypophysis to prompt a compensatory output of thyrotrophic hormone.