1957 Volume 4 Issue 2 Pages 128-135
1) By using the exchange method between L-thyroxine and inorganic radio iodine, it was succeed to get I131 labeled thyroxine with the high specific activity.
2) I131 labeled thyroxine was well metabolized by kidney and liver slice of rat, but not by the other peripheral tissue slices.
3) Kidney slice converted thyroxine into triiodotyronine (or diiodothyronine), inorganic iodide and two unknown compounds (U3 and U4).
4) Live slice converted thyroxine into unknown compounds (U1 and U3) and inorganic iodide, but not convert thyroxine into troiiodothyronine (or diiodothyronine) and the unknown compound named U4.