Endocrinologia Japonica
Online ISSN : 2185-6370
Print ISSN : 0013-7219
ISSN-L : 0013-7219
Volume 4, Issue 2
Displaying 1-8 of 8 articles from this issue
  • EIICHI OGAWA, KUNIO ARAI, KATSUHIRO SHIBATA
    1957 Volume 4 Issue 2 Pages 71-79
    Published: 1957
    Released on J-STAGE: January 25, 2011
    JOURNAL FREE ACCESS
    Using rats of Wistar strain, the effect of various hormones other than the pituitary on the uptake of I131 by the thyroid (2hours value) was investigated.
    Of the tested adrenal hormones including synthetic ones with enhanced activity, cortisone as well as epinephrine and norepinephrine decreased I131 uptake by the thyroid.
    Of the gonadal hormones tested, only estradiol increased it significantly in male rats, but insignificantly in female. Testosterone propionate and androsterone tended to decrease it in male and progesterone acted in a similar manner in both male and female.
    Insulin and thyroxin elicited significant decrease in thyroid uptake of I131.
    Neither parathyroid nor salivary gland hormones produced remarkable change in it.
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  • MASAO FUJIMORI, TAKESHI HIRAYAMA, MASAHIDE HAYASHI
    1957 Volume 4 Issue 2 Pages 80-95
    Published: 1957
    Released on J-STAGE: January 25, 2011
    JOURNAL FREE ACCESS
    1. Eleven cases with malignant changes (10.4%) have been found in 106cases of mastopathia or chronic mastitis in Japanese women.
    2. The tendency was observed that the large cyst formation in mastopathia seemed to be less in Japan than in America and Europe.
    3. Statistically, mastopathia as well as mammary carcinoma in the preclimacteric period occurred most frequently in women who had abortions, abnormal nursings and few children (0-2) in the history.
    4. Hormonal excretions in blood of women who had abnormal childbirth, abnormal nursing and early weaning became irregular in their degree as well as their term; and finally the recovery of progesterone action seemed to be invprsely proportional to the increase of estrogenic action.
    5. In mastopathia, the increase of estrogen and decrease of progesterone in blood (relative hyperestrogenism) was the dominant phenomenon, whereas in mammary carcinoma at the preclimacteric period it was no longer present.
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  • SETSUYA TAKEUCHI, MASUO TOBE, KATSUMI FUKUSHIMA, MASAO KOSUGE, ISAMU S ...
    1957 Volume 4 Issue 2 Pages 96-103
    Published: 1957
    Released on J-STAGE: January 25, 2011
    JOURNAL FREE ACCESS
    1) Changes in blood sugar value elicited by intravenous administration of glucose were investigated with 26 young and 33 adult dogs, and were classified into 4 types-exponential type (type I), humped curve type (type II), sigmoid type (type III) and straight line type (type IV).
    2) Comparison of young and adult dogs with respect to type frequency showed that the so-called atypical type, types II and IV, was found in higher rate in the former than in the latter.
    3) Insulin sensitivity of adult dogs of types I, II and III was investigated, and it was found that insulin sensitivity index for type I was larger than that for types II and III.
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  • HIROSHI AZUMA, MASUZO TATSUGUCHI, RIYOYU TAKEDA
    1957 Volume 4 Issue 2 Pages 104-109
    Published: 1957
    Released on J-STAGE: January 25, 2011
    JOURNAL FREE ACCESS
    The study was made on the quantitative estimation of steroids of allopregnanetetrol and-pentol types, excreted in urine.
    1) The urinary excretion of the aimed steroids amountcd to 1.6-10.0mg per day in healthy adults.
    2) The administration of ACTH or hydrocortisone showed marked increases in their daily excretion. When 50-100mg hydrocortisone was administered, ca.
    9.3-18.7mg was excreted as steroids of allopregnane-tetrol and-pentol types and 8.2-32.6mg as steroids of allopregnane-17, 21-dio1-20-one type respectively.
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  • TAKASHI YAMADA
    1957 Volume 4 Issue 2 Pages 110-119
    Published: 1957
    Released on J-STAGE: January 25, 2011
    JOURNAL FREE ACCESS
    Changes in hypothalamic neurosecretion were observed and brought into comparison with the development of goiter in response to the administration of methylthiouracil.
    Development of goiter followed two phases, viz., acute intial phase and later chronic phase. In the acute phase of goiter development, thyroid does not grow linealy, but shows a temporary growth followed by gradual decline. Such a condition was learned to develop in parallel with a temporary increase in the secretory activity in hypothalamic nuclei, especially in the supraoptic nucleu
    Hyperactivity of supraoptic neurons was observed to be preceded by a remarkable occurrence of red pyknosis of the nucleus and significant acidophily of the perikaryon, the phenomenon being considered to represent certain physiological processes called forth in the face of acute demand of neurosecretory activity. In some of the cells, in which cytoplasmic basophilia are lacking as the consequence of hyperactivity, a characteristic activity of nuclear secretion was observed.
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  • KOJIRO SHICHIJO, TAKASHI YAMADA, TOSHIKAZU SHIMIZU
    1957 Volume 4 Issue 2 Pages 120-127
    Published: 1957
    Released on J-STAGE: January 25, 2011
    JOURNAL FREE ACCESS
    It was observed that, in rats treated with M. T. U., the goiter occurs before any fall of P. B. I. occurs, then it declines conversely when P. B. I. concentration became significantly low. In addition it was observed that P. B. I. concentration in women with various durations and grades of simple goiter in the area of endemic goiter is, in all possibility, within normal range throughout the course of goiter development.
    These facts indicate that the output of thyrotrophic hormone from the anterior pituitary is not always controlled by the level of circulating thyroid hormone and factors other than P. B. I., level would regulate the output of it.
    The disturbance of hormone synthesis would be at first felt by hypothalamic cells, which soon give the stimulation via the portal vessel to the adenohypophysis to prompt a compensatory output of thyrotrophic hormone.
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  • MINORU NAKANO, TOSHIKAZU SHIMIZU
    1957 Volume 4 Issue 2 Pages 128-135
    Published: 1957
    Released on J-STAGE: January 25, 2011
    JOURNAL FREE ACCESS
    1) By using the exchange method between L-thyroxine and inorganic radio iodine, it was succeed to get I131 labeled thyroxine with the high specific activity.
    2) I131 labeled thyroxine was well metabolized by kidney and liver slice of rat, but not by the other peripheral tissue slices.
    3) Kidney slice converted thyroxine into triiodotyronine (or diiodothyronine), inorganic iodide and two unknown compounds (U3 and U4).
    4) Live slice converted thyroxine into unknown compounds (U1 and U3) and inorganic iodide, but not convert thyroxine into troiiodothyronine (or diiodothyronine) and the unknown compound named U4.
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  • HISASHI OKADA
    1957 Volume 4 Issue 2 Pages 136-144
    Published: 1957
    Released on J-STAGE: January 25, 2011
    JOURNAL FREE ACCESS
    1. Almost all steroids, occurring in the Cohn's protein fraction of IV-1, were of conjugated forms with α-globulin, but not in free forms.
    2. Almost all of such bound steroids were dissociated from the serum protein by the treatment of paper electrophoresis, and hydrolysis, but some were still remaining as the conjugated forms even after these treatments.
    3. By the examinations of standard with reference Rf values, fluorescent color and ultraviolet absorption maxima of steroids obtained by paper electrophoresis, relatively small amounts of Comp. F, B and S could be measured in Vp, that represents the peak for absorption of steroids originated from corticoids as previously reported, while those of testosterone, androsterone, dehydroisoandrosterone, progesterone and Comp. F could be measured in IVp, originated from androgens.
    4. Comp. F, Q, S, A, testosterone, dehydroisoandrosterone, androsterone and progesterone were respectively detected in acid-hydrolyzates of this fraction.
    5. The fraction IV-1 showed the highest 17-ketosteroid concentrations, possibly suggesting that the protein-bound 17-ketosteroid of plasma was mainly conjugated with the α-globulin.
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