ENDOCRINOLOGICAL STUDIES ON BREAST CANCER
1957 Volume 4 Issue 2 Pages 80-95
Details
1957 Volume 4 Issue 2 Pages 80-95
1. Eleven cases with malignant changes (10.4%) have been found in 106cases of mastopathia or chronic mastitis in Japanese women.
2. The tendency was observed that the large cyst formation in mastopathia seemed to be less in Japan than in America and Europe.
3. Statistically, mastopathia as well as mammary carcinoma in the preclimacteric period occurred most frequently in women who had abortions, abnormal nursings and few children (0-2) in the history.
4. Hormonal excretions in blood of women who had abnormal childbirth, abnormal nursing and early weaning became irregular in their degree as well as their term; and finally the recovery of progesterone action seemed to be invprsely proportional to the increase of estrogenic action.
5. In mastopathia, the increase of estrogen and decrease of progesterone in blood (relative hyperestrogenism) was the dominant phenomenon, whereas in mammary carcinoma at the preclimacteric period it was no longer present.
