Endocrinologia Japonica
Online ISSN : 2185-6370
Print ISSN : 0013-7219
ISSN-L : 0013-7219
THE INFLUENCE OF ESTRADIOL-17β ON CORTISOL METABOLISM IN VITRO
AKIRA KUMAGAISABURO YANONOZOMU TAKEUCHIKAZUHIKO NISHINOHYO UEDAKEISHI MATSUMOTOKAZUYUKI TAKEUCHI
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1960 年 7 巻 4 号 p. 291-300

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1. The influence of estradiol-17β on cortisol metabolism was studied in vitro using the rat liver homogenate and microsome fraction.
2. It was found in the experiments using homogenates that β4-3-ketone reduction of cortisol was considerably increased following the addition of a given amount of estradiol-17β to the medium and this effect of estradiol-17β became more pronounced under an anaerobic condition or in the presence of potassium cyanide.
3. The stimulatory action of estradiol-17β on cortisol metabolism and its relation to TPNH-generating system were investigated in the purified enzyme system (24, 000×g supernatant fraction). It was found that estradiol-17β was able to replace glucose-6-phosphate system and no effect of estradiol-17β was observed in the presence of TPNH. Similar stimulatory effect of estradiol-17β was noted on aldosterone metabolism.
4. Experiments on estrogen metabolism in microsome fraction of the rat liver showed evidence that the addition of cortisol with TPN increased the production of estrone from estradiol-17β.
5. The results obtained suggest that estradiol-17β acts as a hydrogen donor to TPN to increase the reduction of A-ring of cortisol.
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© The Japan Endocrine Society
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