A PAROTIN-LIKE SUBSTANCE (α-PAROTIN) IN BOVINE PAROTID GLAND IV

STUDIES ON THE PHYSIOLOGICAL CHEMISTRY OF THE SALIVARY GLANDS LXI

Abstract

α-Parotin was distinctly more effective on its hypocalcemic, leukokinetic, and calcification activities than parotin. The optimum dose of α-parotin on the calcification of rabbit incisor dentine was considered to be 50-100μg per kg.α-Parotin was unstable against heat and acid.α-Parotin also was inactivated by ketene, nitrous acid, formaldehyde, and iodine, but not by cysteine and thioglycollie acid. Amino and tyrosine-phenyl groups in α-parotin molecule were responsible for its biological activities.