Endocrine Journal
Online ISSN : 1348-4540
Print ISSN : 0918-8959
ISSN-L : 0918-8959
Adrenal Insufficiency due to Metastatic Hepatocellular Carcinoma
TOSHINARI TAKAMURAYUKIHIRO NAGAIHARUHISA YAMASHITAERIKA NOHARAHITOSHI ANDOMAKIKO KAGAYATAKESHI URABESHUICHI KANEKOKEN-ICHI KOBAYASHI
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1999 Volume 46 Issue 4 Pages 591-596

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Abstract

A 73-year-old man with general malaise and nausea following a common cold diagnosed by a local physician was found to have multiple hepatocellular carcinomas with enlarged bilateral adrenal glands, combined with adrenal insufficiency. Hydrocortisone replacement improved the symptoms and laboratory findings. Autopsy findings revealed that each adrenal gland was completely replaced by the tumor measuring 11cm in diameter, and no adrenal tissue was recognized. Histologically, the adrenal tumors, as well as the liver tumors, were moderately differentiated Edmondson type II hepatocellular carcinomas. This is a second report of adrenal insufficiency due to hepatocellular carcinoma as a primary site of metastatic adrenal tumor.

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