Final Height of Japanese Patients with X-Linked Hypophosphatemic Rickets

Effect of Vitamin D and Phosphate Therapy

Abstract

X-linked hypophosphatemic rickets (XLH) is one of the most common causes of rickets in infancy and childhood. Combination therapy of vitamin D and phosphate is generally used for patients with XLH. Effect of treatment of vitamin D and phosphate during childhood on final height of XLH has to be elucidated in Japanese. There have been only three Caucasian studies on final height of XLH with treatment since childhood. Purpose of this study is to report adult height and therapeutic effect of 22 Japanese participants (5 males, 17 females) with XLH who were treated with phosphate (33-200mg/kg/day as phosphorus divided into 3 or 4 doses) and vitamin D (vitamin D₂ or 1α-hydroxyvitamin D₃) for more than five years and evaluate effect of the treatment on the final height retrospectively. Final height (FHt) for all participants was -1.69±1.11 SD. FHt (-1.69±1.11 SD) was significantly higher than height at the initiation of treatment (-2.38±0.88 SD) for all participants (P<0.01). In conclusion, combination therapy of vitamin D and phosphate improved final height of Japanese patients with XLH as is similar to previous Caucasian studies.