抄録
The binding of Sr to estradiol-induced proteins (EIP) was studied 7 days after a single injection of 17β-estradiol (E2) into goldfish exposed to Sr-enriched water (5, 10, and 15 mg/l). E2 induced hypercalcemia in a way that was negatively correlated with ambient Sr concentration and hyperstrontemia in a way that was positively correlated with the concentration. Diffusible Ca concentrations in plasma remained unchanged in the estrogenized and control fish, while diffusible Sr concentrations increased with an increase in ambient Sr concentration in both the experimental and control fish. Protein-bound Ca and Sr concentrations in plasma were always higher in the estrogenized fish than in the control fish and their levels decreased and increased, respectively, depending on the ambient Sr concentration. The ratios of EIP-bound Sr to ElP-bound Ca increased with an increase in the Sr concentration. These results suggest that Sr competes with Ca for binding to vitellogenin in estrogenized goldfish.
