A CASE OF ENDOCRINE CELL CARCINOMA COMBINED WITH SQUAMOUS CELL CARCINOMA OF THE ESOPHAGUS RESECTED BY ENDOSCOPIC SUBMUCOSAL DISSECTION

KO WATANABE; TAKUTO HIKICHI; MASAKI SATO; JUN NAKAMURA; TADAYUKI TAKAGI; REI SUZUKI; MITSURU SUGIMOTO; YUICHI WARAGAI; HITOMI KIKUCHI; NAOKI KONNO; HIROSHI WATANABE; KATSUTOSHI OBARA; HIROMASA OHIRA

doi:10.5387/fms.2014-2

Case Report

A CASE OF ENDOCRINE CELL CARCINOMA COMBINED WITH SQUAMOUS CELL CARCINOMA OF THE ESOPHAGUS RESECTED BY ENDOSCOPIC SUBMUCOSAL DISSECTION

KO WATANABE, TAKUTO HIKICHI, MASAKI SATO, JUN NAKAMURA, TADAYUKI TAKAGI, REI SUZUKI, MITSURU SUGIMOTO, YUICHI WARAGAI, HITOMI KIKUCHI, NAOKI KONNO, HIROSHI WATANABE, KATSUTOSHI OBARA, HIROMASA OHIRA

Author information

KO WATANABE
Department of Gastroenterology and Rheumatology School of Medicine, Fukushima Medical University
Department of Endoscopy, Fukushima Medical University Hospital
TAKUTO HIKICHI
Department of Endoscopy, Fukushima Medical University Hospital
MASAKI SATO
Department of Gastroenterology and Rheumatology School of Medicine, Fukushima Medical University
JUN NAKAMURA
Department of Gastroenterology and Rheumatology School of Medicine, Fukushima Medical University
TADAYUKI TAKAGI
Department of Gastroenterology and Rheumatology School of Medicine, Fukushima Medical University
REI SUZUKI
Department of Gastroenterology and Rheumatology School of Medicine, Fukushima Medical University
MITSURU SUGIMOTO
Department of Gastroenterology and Rheumatology School of Medicine, Fukushima Medical University
YUICHI WARAGAI
Department of Gastroenterology and Rheumatology School of Medicine, Fukushima Medical University
HITOMI KIKUCHI
Department of Gastroenterology and Rheumatology School of Medicine, Fukushima Medical University
NAOKI KONNO
Department of Gastroenterology and Rheumatology School of Medicine, Fukushima Medical University
HIROSHI WATANABE
Department of Gastroenterology and Rheumatology School of Medicine, Fukushima Medical University
KATSUTOSHI OBARA
Department of Endoscopy, Fukushima Medical University Hospital
HIROMASA OHIRA
Department of Gastroenterology and Rheumatology School of Medicine, Fukushima Medical University

Keywords: endocrine cell carcinoma (ECC), endoscopic submucosal dissection (ESD), esophageal cancer, narrow band imaging (NBI), combined cancer

JOURNAL OPEN ACCESS FULL-TEXT HTML

2014 Volume 60 Issue 2 Pages 187-191

DOI https://doi.org/10.5387/fms.2014-2

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Abstract

A 55-year-old man with esophageal carcinoma received endoscopic submucosal dissection (ESD) in en-bloc resection. Histopathological examination revealed an admixture of squamous cell carcinoma (SCC) and endocrine cell carcinoma (ECC) with invasion of the deep submucosa. Immunohistochemically, CD 56 and chromogranin A were positive for ECC. Small-cell, medium-cell, and large-cell type ECC were partly surrounded with SCC and partly formed the duct, presenting various patterns. After ESD, he received chemotherapy including CPT-11 plus Cisplatin. He is alive and in good condition today, 55 months after ESD, with no evidence of recurrence.

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