日本薬理学雑誌
Online ISSN : 1347-8397
Print ISSN : 0015-5691
ISSN-L : 0015-5691
ヒトゲノムプロジェクトと創薬
大久保 公策
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ジャーナル フリー

1996 年 108 巻 supplement 号 p. 9-12

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Expression profile is a list of genes acting in a tissue. It is made by measuring the occurence of each transcript by random sequencing of clones from 3'-directed cDNA library made from a tissue. Since 3'-directed libraries faithfully represent the molecular composition in material mRNAs, the occurence of any GS reflects the abundance of corresponding transcript in the source tissue.
BodyMap is made by compiling Expression Profiles of various tissues. In the BodyMap, the expression strength of genes, known or novel, are given as a function of tissues or cell types. At present, we have collected expression information of over 12000 genes among 43 different tissues.
Using this database, tissues can be characterized by their gene expression and genes can be categorized by their expression pattern. Tissue specific, hosekeeping, characteristic to cancers, any sort of genes can be selected from the BodyMap by in silico experiments.
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