抄録
Ten per cent of sulfathiazol was mixed into three kinds of ointment base respectively, i.e. lanolin-vaselin, hydrophilic ointment and propylene glycol-carbowax, to each of which was also added the non-ionic surface active agent, Span 60 or G 2162 (Atlas). The ointment, thus prepared, was applied on the wound surface on the back of rabbits and kept for 6 hours. The amount of sulfathiazol in urine and blood was then chemically measured and compared with the resultin the case without addition of surface active agents. Result : (1) Span 60 has no effect on the absorption of sulfathiazol when mixed into the oily base (that is, lanolin-vaselin), while G 2162 causes the increase only when applied in the form of the same base ointment, the sulfa-drug of which is, however, not less than 0.5 per cent. (2) The absorption of sulfathiazol contained in the hydrophilic ointment is increased by the addion of G 2162, and by Span 60 it is unaffected, if any, a little. (2) In the case of the propylene glycol base oitment both of surface active agents cause almost no effect.
