日本薬理学雑誌
Online ISSN : 1347-8397
Print ISSN : 0015-5691
ISSN-L : 0015-5691
49 巻 , 4 号
選択された号の論文の16件中1~16を表示しています
  • 大味谷 輝男
    1953 年 49 巻 4 号 p. 159-168,en21
    発行日: 1953/09/20
    公開日: 2011/09/07
    ジャーナル フリー
    The curarimimetic and anticonvulsant activity activity of 3- (1, 2, 3, 4-tetrahydro-8-naphthyloxy) propane-1, 2-diol (=ar.α-Tetralyl glycerol ether, abbreviated as α-TNP and 3- (1, 2, 3, 4-tetrahydro-7-naphthyloxy) propane-1, 2-diol (=ar.β-Tetralyl glycerol ether, abbreviated as β-TNP) has been studied and the latter was found to have a stronger power and a longer duration than those hitherto tested including Myanesin. As appendices the analogous action of m-tolyl glycerol ether, m-ethylphenyl glycerol ether, α-naphthyl glycerol ether, and β-naphthyl glycerol ether has been studied which could not have an equal even to Myanesin.
  • 大味谷 輝男
    1953 年 49 巻 4 号 p. 169-171,en21
    発行日: 1953/09/20
    公開日: 2011/09/07
    ジャーナル フリー
    The re-examinations have been carried out on the basis of Ginzel's report [K. H. Ginzel et al. : Wien. med. Wschr. 99, 299 (1949)] and it has been proved that 5% fructose prevented. completely the thrombosis induced after 2 % Myanesin and 10% fructose did as well for 5 % Myanesin, while the preventive effect of glucose was inferior to that of fructose.
  • 佐藤 耀一
    1953 年 49 巻 4 号 p. 172-203,en21
    発行日: 1953/09/20
    公開日: 2011/09/07
    ジャーナル フリー
    The experiments have been carried out with a special apparatus of a simply closed type designed by author for the determination of basic metabolism of rats under the influence of drugs in recording the respiratory gaseous volume. Result : (1) Sulphonamides inhibit in general the basic metabolism. (2) Cardiac stimulants including n-hydroxy-camphor accelerate the gaseous metabolism; on the contrary, camphor inhibits. (3) The basic metabolism is decreased by phenobarbital and increased by the central stimulants. (4) The antihistaminics, N-dimethylaminoethyl phenotiazine HCl accelerates, while Benadryl inhibits. (5) With the sympathomimetics, benzylimidazoline HCl accelerates, and with TEAB there exists the inhibition, if any, but very weak.
  • 小笠原 忠雄
    1953 年 49 巻 4 号 p. 204-209,en22
    発行日: 1953/09/20
    公開日: 2011/09/07
    ジャーナル フリー
    Studies on the pyrogen tolerance, reported formerly by M. Kobayashi (this Breviaria of vol. 47, p. 5 ξ, nos. 10 & 11) were more widely and precisely carried out. Result : When a certain intravenous dose of the filtrate of Escherichia coli culture. media, which had assayed biologically by means of investigation on the Schwartzman's phenomenon in rabbits and standardized uniformly, were given to rabbits once a day or, sometimes, with an interval for three days, the tolerance was proved acquired against the very pyrogen on animals after 5-7 days from the first injection, which lasted four weeks at least.
  • 伊藤 信也
    1953 年 49 巻 4 号 p. 210-221,en22
    発行日: 1953/09/20
    公開日: 2011/09/07
    ジャーナル フリー
    The interaction of several sympathomimetic amines and others was studied and the mode of action of these amines was discussed. Generally speaking, the action of amines was sensitized by each other in lower concentrations, and their actions were proved only as additive. In higher concentrations the effects of amines were antagonized by each other, where the effect of tyramine, sympatol, etc., particularly that of ephedrine, was completely abolished. or reversed. From the results obtained it was supposed that the actions of these amines were quite resembled and the site of actions was likely on the adrenergic receptor.
  • 荻生 規矩夫, 藤田 貞雄, 安原 基弘
    1953 年 49 巻 4 号 p. 222-226,en22
    発行日: 1953/09/20
    公開日: 2011/09/07
    ジャーナル フリー
    An experiment using the isolated papillary muscle from the rabbit was described, which proved it as a satisfactory material for the bioassay of digitalis preparations in a certain condition of experiments and this result was compared with those with the same muscle from the cat, where the relative potencies were determined on the following preparations as to their therapeutic effects and toxicity : digitoxin, strophanthine, digicorin and powdered digitalis leaves.
  • 荻生 規矩夫, 藤田 貞雄, 安原 基弘, 藤澤 利和, 小川 保直
    1953 年 49 巻 4 号 p. 227-230,en22
    発行日: 1953/09/20
    公開日: 2011/09/07
    ジャーナル フリー
    The potencies as to therapeutic and toxic effects of several digitoxin preparations were comparatively determined by the biological methods. The digitoxin preparation which contained gitoxin was less toxic than the pure, in which there was, however, no obvious difference in the therapeutic effect between them. Therefore, the standardization of digitoxin preparations should be carefully undertaken with the biological methods in various ways, not of a single sort.
  • 島田 光夫
    1953 年 49 巻 4 号 p. 231-236,en23
    発行日: 1953/09/20
    公開日: 2011/09/07
    ジャーナル フリー
    The author has studied the toxicity of the coelomic fluid the body-constituents of round-worms against mice as well as their action of the ocular mucous membrane of rabbits and guinea pigs, and arrived at the following observations in summary. 1) An intravenous injection of 1.0 cc/10 g kills likely no mouse, but 0.3-0.5 cc/10g of body extract similarly administered frequently kills it. In both cases, the toxic symptoms are of the same nature, shock being always conspicuously observable. If the toxinosis is protracted over long hours, congestion and hemorrhage become manifest in internal organs and tissues. In mice, individual difference is not noticeable. 2) Applied to the eyes of rabbits, both the coelomic fluid and the body extract in water cause symptoms of acute conjunctivitis in the mucous membrane, accompanying edema, tumescence, abundant lacrimation and sebum secretion. Body extract in alcohol, ether, chloroform and acetone cause only slight symptoms chiefly of congestion in the mucous membrane, copious lacrimation and sebum secretion, while edema and swelling are not noticeable. In the eyes of rabbits and guinea pigs, similar results have been observed. Such toxic reactions to the eyes seem to be due to the direct action of the round-worm poison against the blood vessel walls in the ocular mucous membrane.
  • 島田 光夫
    1953 年 49 巻 4 号 p. 237-247,en23
    発行日: 1953/09/20
    公開日: 2011/09/07
    ジャーナル フリー
    Subsequent to the experiments reported in the first issue in this series, the author studied the action of the coelomic and somatic fluids on excised hearts of frogs, the excised vessels of hind legs of toads, , the ear vessels of rabbits, the blood pressure and respiration in rabbits, and excised intestine and uteri of rabbits. The results obtained were as follows : Against the excised hearts of frogs, their reaction was directed against the cardiac muscles, depressantly in high concentration and stimulantly in low concentration. Against the peripheral blood vessels, they caused constriction in high concentration and dilatation in low concentration to the auricular vessels of rabbits, but to the excised vessels of hind legs of toads, the action was generally constrictive regardless of the concentration. Against blood pressure, coelomic fluid acted to heighten it at first and then depressantly, but the body extract always tends to depress it. This action anent the blood pressure is influenced neither by the central nor the vagal nerves. Respiration generally becomes shallow and slow, but in some cases, its frequency is enhanced. In respect of the movement of smooth muscle organs, I found that the coelomic fluid causes a passing depression of the autonomic movement of the excised intestine of rabbits, but the body extract containing fat tended to stimulate such movement. Such effects are seemingly caused by the direct attack on the muscles themselves by the fluids. Against the isolated uterus of rabbits, both the preparations acted stimulatingly to their autonomic movement. In looking over the observed actions of the round-worm poison, I found that not only the protein containing, but also the fat containing constituents in the body-extracts of the nematoda play a part in the occurrence of the biological reactions.
  • 工藤 次郎
    1953 年 49 巻 4 号 p. 248-254,en24
    発行日: 1953/09/20
    公開日: 2011/09/07
    ジャーナル フリー
    The local anesthetic efficacy of the crystalline alkaloids, quinine, quinidine and cinchonine, was studied, using corneae of rabbits and sciatie nerves of frogs for the tests, in mutual comparison and in comparison with cocaine and percaine. The results were summarized as in the following : 1) All the three cinchona alkaloids showed efficacy in local anesthetizing, but they were weaker, than cocaine in this respect. 2) Among the three, quinidine showed the strongest and cinchonine the weakest efficacy on the corneae of rabbits, quinine coming between the two, while in the tests with the frog's sciatic nerve, quinine and quinidine were almost equally efficacious, cinchonine being only slightly anesthetic.
  • 工藤 次郎
    1953 年 49 巻 4 号 p. 255-267,en24
    発行日: 1953/09/20
    公開日: 2011/09/07
    ジャーナル フリー
    The author has observed the effect of berberine, condurangin, eugenol and caryophyllene, the effective ingredients extracted from four stomachics, on the blood picture of rabbits. In the experiments, the chemicals were administered subcutaneously or intravenously in single dosis or in successive injections. The effects on the blood picture was examined in normal rabbits and in rabbits made anemic with phenylhydrazine and toluylenediamine. The results may be summarized as follows : 1) None of the four tested chemicals had any effect on the blood picture of rabbits in normal health. 2) Berberine was found efficacious against both types of anemia, while the other 3 chemicals showed a slight effect against the toluylenediamine-induced anemia only.
  • 關谷 淳
    1953 年 49 巻 4 号 p. 268-281,en25
    発行日: 1953/09/20
    公開日: 2011/09/07
    ジャーナル フリー
    The action of ATP, phosphocreatine (PHC) and their related compounds was investigated on the perfused isolated hearts of mammalia and amphibia. Result : ATP and ADP increased the amplitude of mammalian and amphibian heart contraction after a temporary decrease and greatly increased the rate of coronary flow of the mammalian heart, while PHC showed no increase in the rate of mammalian coronary flow, but it increased the amplitude of both hearts' contraction with no temporary decrease followed.
  • 白髭 壽男
    1953 年 49 巻 4 号 p. 282-288,en25
    発行日: 1953/09/20
    公開日: 2011/09/07
    ジャーナル フリー
    Ten per cent of sulfathiazol was mixed into three kinds of ointment base respectively, i.e. lanolin-vaselin, hydrophilic ointment and propylene glycol-carbowax, to each of which was also added the non-ionic surface active agent, Span 60 or G 2162 (Atlas). The ointment, thus prepared, was applied on the wound surface on the back of rabbits and kept for 6 hours. The amount of sulfathiazol in urine and blood was then chemically measured and compared with the resultin the case without addition of surface active agents. Result : (1) Span 60 has no effect on the absorption of sulfathiazol when mixed into the oily base (that is, lanolin-vaselin), while G 2162 causes the increase only when applied in the form of the same base ointment, the sulfa-drug of which is, however, not less than 0.5 per cent. (2) The absorption of sulfathiazol contained in the hydrophilic ointment is increased by the addion of G 2162, and by Span 60 it is unaffected, if any, a little. (2) In the case of the propylene glycol base oitment both of surface active agents cause almost no effect.
  • 荻生 規矩夫, 藤村 一, 松村 元始, 上島 孝治
    1953 年 49 巻 4 号 p. 289-295,en25
    発行日: 1953/09/20
    公開日: 2011/09/07
    ジャーナル フリー
    4-α-Dimethylaminopropionylaminoantipyrine (No. 7) showed a far stronger analgesic action and a far weaker toxicity than aminopyrine (A), but no antipyretic action (J. Pharm. Soc. Jap. 73, 437, 1953). In the case of a combined use of both drugs the analgesic action was synergistically increased and the antipyretic action of A in febrile rabbits was elevated. No. 7 raised also the solubility of A and reduced its toxicity. Further, the influence of adrenolytics as priscoline and cholinergics as prostigmine on the analgesic action of No. 7 and A was investigated.
  • 左近 さくら
    1953 年 49 巻 4 号 p. 296-313,en26
    発行日: 1953/09/20
    公開日: 2011/09/07
    ジャーナル フリー
    The gonadotropic activity was assayed biologically with the urine of the two castrated women. The effects of the gonadotropic hormone were found to be different from that of the urine of pregnant women. Using numerous successive extraction of the gonadotropic hormone with the specimens, an efficient extraction was achieved by the addition of acetone to the final concentration of 65 vol. %. The final product was obtained in the form of powder. Koyama's method of hypophysectomy in rats improved to be performed with mature rats. The urinary gonadotropic hormone in the castrated was proved to be hypophyseal from the experiment with hypophysectomized rats.
  • 1953 年 49 巻 4 号 p. a171-a201
    発行日: 1953/09/20
    公開日: 2011/09/07
    ジャーナル フリー
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