組織透過性に対する諸種薬物の影響

(第5報) 戸紙埋没ラットの上部皮膚組織透過性試験による諸種抗炎症剤の効力比較

抄録

Slowly developing inflammation was induced by subcutaneous implantation of a piece of sterilized filter paper (25×35 mm) in the ventral region of the rat. The dermal tissue permeability on the implanted filter paper was measured by means of spreading method and the following results were obtained.
1) The permeabili ty was increased rapidly after implantation and was reached a peak after 5 days (6.2 times higher than normal). It thereafter was decreased slowly along with development of granulation tissue and was returned to the first level by 2 weeks when granulation tissue reached a maximum.
2) Increased tissue permeability of 3 days after implantation was inhibited significantly by various anti-inflammatory agents administered orally or subcutaneously once a day to the 4 th day. The intensity of the inhibitory effect following oral administration was roughly the next order.: Dexamethasone>Prednisolone>Hydrocortisone acetate>Indomethacin>Cortisone acetate>Benzydamine Hcl≈Chloroquine diphosphate>Bucolome≈Phenylbutazone=Flufenamic acid>Aminopyrine>Mefenamic acid>Na-salicylate>Acetylsalicylic acid. Cyproheptadine HCl and homochlorcyclizine also showed significant activity at the dose of 50 mg/kg p. o..
3) As this experiment is possible to alter freely the times and periods of drug administration and to estimate anti-inflammatory activity following postmedications, it seems to be worth as one of methods for the evaluation of the potency of anti-inflammatory agents.