新中枢性鎮痛薬1-(m-methoxy phenyl)-2-dimethyl-aminomethylcyclohexanol (1) HCl[CG-315]の代謝消長に関する研究

抄録

1) Subcutaneous administration of CG-315 to rats was followed by rapid absorption and distribution, especially highly in lung, spleen, liver, and kidney etc. Most of the injected drug was excreted in the urine within 24 hrs and a few in the feces.
2) Part of absorbed CG-315 may be mainly metabolized in liver to either O- or N-demethylated forms, some of which are conjugated with glucuronate.
3) No difference was found in metabolism of CG-315 between non-tolerant and tolerant rats.