Antioxidative and Antihyaluronidase Activities of Some Constituents from Foeniculi Fructus (Fruit of Foeniculum vulgare MILLER)

Abstract

The inhibitory effects of some constituents which were previously isolated from the MeOH extract of Foeniculi Fructus (Fruit of Foeniculum vulgare MILLER) were investigated on the oxidation of linoleic acid and on the activation of inactive hyaluronidase induced by compound 48/80. Among the test compounds, six stilbene trimers, miyabenol C, cis-miyabenol C, foeniculoside I, foeniculoside II, foeniculoside III and foeniculoside IV, exhibited greater antioxidative activities than BHA. Furthermore, miyabenol C and cis-miyabenol C showed strong hyaluronidase inhibitory effects.