抄録
Arsenic is a hazardous element that exists widely in the environment. To elucidate the molecular mechanism involved in the onset of arsenic toxicity, we comprehensively searched for genes affecting the sensitivity of HEK293 cells to arsenite by using a siRNA library targeting approximately 17,000 human genes. As a result, we identified ACOT9, one of the acyl-coenzyme A thioesterases, as the gene conferring arsenite resistance to cells by knockdown.
