抄録
Twenty cases of duodenal ulcer were studied on the distribution of the immunoglobulin in the biopsy specimens by immunohistochenical and immunoquantitative method, and the following results were obtained. 1) IgA, IgM, IgG, and the secretory component in each stage of duodenal ulcer were studied, more IgA-containing cells were observed in the active stage and had generally strong specific fluorescence, its leakage into the lamina propria and the stroma was recognized and it returned to the normal level following to modification. 2) IgM containing cells decreased in the active stage and increased in the scarring stage. 3) IgG containing cells stayed unchanged in each stage, and the specificity of fluorescence in the propria mucosa was strong. 4) In the active stage, the specificity of fluorescence of the secretory component decreased and was not observed in some epithelial cells. 5) IgM and IgE of the serum immunoglobulin increased and IgA decreased in the active stage. 6) The changes described above suggest the possibility of duodenal ulcer as immune disease.
