抄録
The pathophysiological approach of the atrophic border in chronic gastritis has been made by means of dying endoscopy, magnifying endoscopy and others. In this paper, discussions were made on the association of serum gastrin and gastric mucosal atrophy. Serum gastrin, in both of during fasting and after loading of the meat extract, was estimated by radioimmunoassy. There was not a significant difference in normal subjects and patients with duodenal or gastric ulcer. Fasting serum gastrin, and maximum amount and response pattern after loading proportionaly related directly to the atrophic grade of the pyloric gland area. Concerning to the atrophic border, serum gastrin increased in proportion to the elevation of the border to the fundus in closed type by Kimura and Takemoto's classification. While, in open type, serum gastrin level generally tended to decrease.
