Exploration of novel organic-inorganic complex molecules in nature: Optimization and perspectives of hybrid cross-separation with high-resolution mass spectrometry

Abstract

There are a wide variety of organic compounds in nature. The samples from the asteroid Ryugu contains more than 20,000 molecules [1]. The evidence of important organic molecules and tautomerism due to aqueous alteration has also been identified [e.g., 2,3]. The molecular formula of alanine, a representative amino acid, is C3H7NO. Theoretically, the chemical structures with this molecular formula exist in over 50 varieties, including structural isomers and D-, L-enantiomers. In the present study, we discuss the method development in chromatography (LC/IC, GC) and in electrophoresis (CE) which high-resolution mass spectrometry (HRMS).[1] Naraoka et al. Science 379, eabn9033 (2023). [2] Takano et al. Nature Commun. 15, 5708 (2024). [3] Oba et al. Nature Commun. 14, 3107 (2023).