抄録
The present paper deals with a) a gross comparison of the embryonic stage in CF-1 mice, Sprague Dawley rats and albino rabbits, b) the relationship between the stage at which hypervitaminosis A was administered and the incidence of fetal deaths including embryonic losses as well as of limb and digital malformations, and c) the relationship between various dose levels of hypervitaminosis A and malformation of the extremities in the three species.
Generally, susceptibility expressed by fetal deaths, including embryonic losses, seems to be the highest in the rabbit, next in the mouse, and the lowest in the rat, while susceptibility of limb buds and hand or foot plates to the teratogenic action of hypervitaminosis A seems to be the highest in the mouse, next in the rat and the lowest in the rabbit.
