Consistency of the results of rapid serological tests for SARS-CoV-2 among healthcare workers in a large national hospital in Tokyo, Japan

Shohei Yamamoto; Akihito Tanaka; Shinji Kobayashi; Yusuke Oshiro; Mitsuru Ozeki; Kenji Maeda; Kouki Matsuda; Kengo Miyo; Tetsuya Mizoue; Wataru Sugiura; Hiroaki Mitsuya; Haruhito Sugiyama; Norio Ohmagari

doi:10.35772/ghm.2021.01022

Original Article

Consistency of the results of rapid serological tests for SARS-CoV-2 among healthcare workers in a large national hospital in Tokyo, Japan

Shohei Yamamoto, Akihito Tanaka, Shinji Kobayashi, Yusuke Oshiro, Mitsuru Ozeki, Kenji Maeda, Kouki Matsuda, Kengo Miyo, Tetsuya Mizoue, Wataru Sugiura, Hiroaki Mitsuya, Haruhito Sugiyama, Norio Ohmagari

Author information

Shohei Yamamoto
Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan.
Department of Rehabilitation Sciences, Kitasato University Graduate School of Medical Sciences, Kanagawa, Japan.
Akihito Tanaka
Department of Laboratory Testing, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
Shinji Kobayashi
Department of Laboratory Testing, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
Yusuke Oshiro
Department of Laboratory Testing, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
Mitsuru Ozeki
Department of Laboratory Testing, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
Kenji Maeda
Department of Refractory Viral Infection, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Kouki Matsuda
Department of Refractory Viral Infection, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Kengo Miyo
Center of Medical Informatics Intelligence, National Center for Global Health and Medicine, Tokyo, Japan.
Tetsuya Mizoue
Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan.
Wataru Sugiura
Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan.
Hiroaki Mitsuya
Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Haruhito Sugiyama
Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
Norio Ohmagari
Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.

Keywords: COVID-19, serological tests, SARS-CoV-2, seroprevalence, immunoassay

JOURNAL FREE ACCESS

2021 Volume 3 Issue 2 Pages 90-94

DOI https://doi.org/10.35772/ghm.2021.01022

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Abstract

We assessed the consistency of seropositive results of three rapid immunoassays (Kits A, B, and C) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compared to highly accurate serological tests (Abbott and Roche) among healthcare workers in a hospital in Tokyo. The seroprevalence of SARS-CoV-2 immunoglobulin G was 0.41%, 2.36%, and 0.08% using Kits A, B, and C, respectively. Of the 51 samples that were seropositive on any rapid test, all were seronegative on both the Abbott and the Roche assays. Given that the seroprevalence of SARS-CoV-2 immunoglobulin G varied widely according to the choice of rapid test and the rapid test results were inconsistent with the results of highly accurate tests, the diagnostic accuracy of rapid serological tests for SARS-CoV-2 should be assessed before introducing these tests for point-of-care testing or surveillance.

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