抄録
Our previous studies on murine cytidylate cyclase clarified that the activities were highest in brain among several tissues tested including liver, heart, kidney, spleen, and lung. In the present study, human brain cytidylate cyclase activities were compared with those of different types of brain tumors. The activity of cytidylate cyclase, which catalyze formation of cytidine 3',5'-cyclic monophosphate (cCMP) from cytidine 5'-triphosphate (CTP), was assessed by enzyme immunoassay (ETA) developed in our laboratory.
It was shown that human normal brain had a cytidylate cyclase activity as high as those of murine brain, which could be solbilized with 0.3% (v/v) Triton X-100.
There was a great variety in the enzyme activity of human brain tumors, glioblastoma shown to be low and meningioma to be high.
These findings suggest that this enzyme might be used as a marker of the tumor malignancy.
