Pre and postoperative values of serum uric acid and 24 hr urinary excretion of uric acid were measured in 29 patients with primary hyperparathyroidism. Serum uric acid levels were 6.0 ± 1.0 mg/dl and 6.0 ± 0.6 mg/dl in males, and 5.7 ± 0.8 mg/dl and 5.3 ± 0.1 mg/dl in females, respectively pre and postoperatively. No significant change was observed. Positive correlation (p<0.01) was found between the ratios of Ca/Creatinine and Uric Acid/Creatinine before but not after operation. Serum uric acid levels increased on first to third days after operation and returned normal within a week. Under low calcium diet for five days, serum uric acid levels were elevated. These findings suggest that primary hyperparathyroidism has some influences on uric acid metabolism.
