尿酸
Online ISSN : 2187-0098
Print ISSN : 0388-4120
ISSN-L : 0388-4120
痛風患者における末梢血多形核白血球のchemiluminescence(化学発光)の検討
松本 美富士山本 正彦菅原 譲三井 忠夫円羽 滋郎
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1984 年 8 巻 2 号 p. 193-198

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We investigated luminol-dependent chemiluminescence (LDCL) of peripheral blood polymorphonuclear neutrophils (PMNs) from gouty patients. The reaction mixture consisted of peripheral PMN, luminol solution and opsonized Zymosan. In acute gouty arthritis, LDCL of PMNs was enhanced more prominently than that of asymptomatic patients and healthy volunteers. A serial measurement of LDCL revealed that enhancement of LDCL was only associated with episodes of acute gouty. When colchicine was administered during acute gouty attacks, enhancement of LDCL was suppressed. However, this suppression was more prominent in patients with Behcet's disease who were administered colchicine continuously. No significant correlation was found between serum uric acid levels and LDCL.

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