抄録
The increase in serum uric acid (UA) after smoking cessation was evaluated. Materials and methods: Annual health check-up data for 7805 males obtained in the years 1996 and 2000 were analyzed longitudinally. Result: Among those who were smokers in 1996 (n=4836,62%) but had quit smoking by 2000 (n=369; annual quitting rate 1.2%), serum uric acid increased by 0.68 mg/dl. This increase of 0.68 mg/dl (SE=0.055) over the baseline was much greater than the increase of 0.31 mg/dl (SE=0.026) in nonsmokers (P<0.001). Although quitters showed an increase in body weight of 1.67 kg (SD=3.92), the increase in UA was suggested to be much greater than that expected from the increase in body weight gain alone (P<0.001). Conclusion: Weight gain after smoking cessation was considered to regress towards normal and/or regular weight in this cohort. The increase in UA was greater than that expected from weight gain, suggesting the presence of a factor that suppresses UA levels in smokers. Smokers with smoking UA levels around 6 mg/dl can expect an increase in UA by 1-2 mg after smoking cessation. This suggests the relative importance of weight gain over that assumed as well as life style factors such as alcohol consumption in supporting the continuation of smoking cessation.
