Glycative Stress Research
Online ISSN : 2188-3610
Print ISSN : 2188-3602
ISSN-L : 2188-3610
Antiglycative effect of black galangal, Kaempferia parviflora Wall. Ex. Baker (Zingiberaceae)
Masayuki Yagi Kayoko InoueYasuo SatoKaori IshizakiChieko SakiyamaYoshikazu Yonei
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ジャーナル オープンアクセス

2021 年 8 巻 1 号 p. 1-7

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Accumulation of advanced glycation endproducts (AGEs) in the body due to glycative stress is a factor in the onset of aging and lifestyle-related diseases. Suppression of glycative stress in the body is called anti-glycation, and includes suppression of postprandial hyperglycemia, suppression of glycative reaction, and decomposition and excretion of AGEs. It is already known that plant materials, i.e., vegetables and herbs, have an anti-glycative effect. Of these, the rhizome of black galangal (Kaempferia parviflora Wall. Ex. Baker; KP), which is a type of ginger family plant (Zingiberaceae), has an action of suppressing the formation of fluorescent AGEs, and polymethoxy flavonoids (PMF); and hydrophilic components are thought to be involved as the active components. In this study, for the purpose of further verifying the possibility of KP as an anti-glycation material, we focused on the hydrophilic component in the KP rhizome and evaluated the anti-glycative effect and AGE decomposition action. As a sample, a hot water (80°C) extract of dry KP rhizome was used. The anti-glycative effect of the KP extract was examined for actions of inhibiting the formation of AGEs and intermediates in the human serum albumin (HSA)-glucose glycation model. Regarding the degrading action of AGEs, the cleaving action of AGE cross-links and the enhancing action of oxidized protein hydrolase (OPH) activity. In the results, the KP extracts inhibited the formation of fluorescent AGEs, pentosidine, CML (Nε-carboxymethyllysine) and intermediates, 3-deoxyglucosone (3DG), glyoxal solution (GO) and methylglyoxal solution (MGO). For the decomposition effect, the KP extract enhanced actions of both cross-link cleaving of AGEs and OPH activity. In conclusion, it is indicated that KP, as an anti-glycative material, can suppress the production of many types of AGEs with different pathways and acts on the decomposition of AGEs, thus reducing the amount of accumulated AGEs in the body.

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© 2021 Society for Glycative Stress Research
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