Abstract
The therapeutic efficacies of Streptomycin, Tibion, PAS, Promin & Cepharanthin, especially of their combinations, on the development of rat leprosy, were studied.
The results were as follows.
1) Evaluating the therapeutic effectiveness of the agents on rat leprosy, based upon the degree of the enlargment of leproma and the dissemination of lepra bacilli into tissues, it appeared the most activity for Streptomycin and better for Promin. On the other hand, in the limited type of our experiment, the administration of Pas, Tibione & Cepharanthin did not show any significant therapeutic effect on rat leprosy.
2) The inhibitory activity of Streptomycin in combination with Promin proved to he inferior to that each used alone.
3) Contrary to that, Streptomycin or Promin being used along with Pas, Tibion & Cepharanthin, it was show to act even antagonistically each other.
