Repura
Online ISSN : 2185-1352
Print ISSN : 0024-1008
ISSN-L : 0024-1008
Volume 22, Issue 1
Displaying 1-9 of 9 articles from this issue
  • Report I. Observations on the Non-acidfast Type of Initial Microcolonies of Acid-fast Bacilli
    Kenji Yasumoto
    1953 Volume 22 Issue 1 Pages 1-11
    Published: January 20, 1953
    Released on J-STAGE: June 30, 2008
    JOURNAL FREE ACCESS
    As the results of the studies on the initial developmental forms and staining properties of acid-fast bacilli, especially of tubercle bacilli, the author found the following facts :
    1) The findings obtaining herein the developmental forms of acid-fast bacilli, especially of tubercle bacilli, corresponded with those reported by many investigators.
    2) The splitting, branching and budding forms in growth types of acid-fast bacilli were recogniged.
    3) It seemed that there were not always clear parallel apprehensions between the staining property and the degree of acid-fastness of acid-fast bacilli.
    4) The frequency of so-called non-aci.dfast type of acid-fast bacilli, especially of tubercle bacilli, was not only due to the degree of the acid-fast property of their strains, but to their developing stages, states, and circumstances.
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  • Report II. On the Granules of Acid-fast Bacilli Observed by Various Procedures
    Kenji Yasumoto
    1953 Volume 22 Issue 1 Pages 12-17
    Published: January 20, 1953
    Released on J-STAGE: June 30, 2008
    JOURNAL FREE ACCESS
    Studying on the granules of acid-fast bacilli observed by using the various staining procedures, the author found the following results:
    1) The small bodies or granules observed at the bilateral poles of non-stained acidfast bacilli seem to be differ from those at the central part of them.
    2) The granules at the bilateral poles in acid-fast bacterial bodies which were recognized by the use of the Tellurite reaction method, Oxydation method, and such the staining methods as Giemsa's, Ziehl-Neelsen's, and Ziehl-Heidenhain's seem to be all same, and to be same as a part of granules observed in the non-staining or Gram's staining, specimens.
    3) The Fontes' granules seem to be differ from the Ziehl's granules, in view of their appearing parts and states in the acid-fast bacterial bodies.
    4) The appearing states of the granules which show positive Feulgen's reaction in the bacterial bodies somewhat resemble with those of the Ziehl's and Fontes' granules but with reference to the existing part Feulgen's granules seem to resemble or correspond with the granules exsisting in the central part of the bacterial bodies.
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  • Studies on Rat Leprosy (22)
    Yasuro Takayama, Kenji Yasumoto
    1953 Volume 22 Issue 1 Pages 18-22
    Published: January 20, 1953
    Released on J-STAGE: December 10, 2008
    JOURNAL FREE ACCESS
    The therapeutic efficacies of Streptomycin, Tibion, PAS, Promin & Cepharanthin, especially of their combinations, on the development of rat leprosy, were studied.
    The results were as follows.
    1) Evaluating the therapeutic effectiveness of the agents on rat leprosy, based upon the degree of the enlargment of leproma and the dissemination of lepra bacilli into tissues, it appeared the most activity for Streptomycin and better for Promin. On the other hand, in the limited type of our experiment, the administration of Pas, Tibione & Cepharanthin did not show any significant therapeutic effect on rat leprosy.
    2) The inhibitory activity of Streptomycin in combination with Promin proved to he inferior to that each used alone.
    3) Contrary to that, Streptomycin or Promin being used along with Pas, Tibion & Cepharanthin, it was show to act even antagonistically each other.
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  • Yoichiro Kawaguchi
    1953 Volume 22 Issue 1 Pages 23-27
    Published: January 20, 1953
    Released on J-STAGE: June 30, 2008
    JOURNAL FREE ACCESS
    This paper presents the effects of hyaluronidase on rat leprosy.
    1) Rat leprosy bacilli were injected intracutaneously into white rats as follows: a) together with hyaluronidase; b) injected at a site into which hyaluronidase was injected one hour before; c) bacilli injected alone as controls. The effects of hyaluronidase were not found on this experiment.
    2) Rat leprosy bacilli were injected subcutaneously into white rats, alone and with hyaluronidase.
    Hyaluronidase accelerated the development of granuloma on subcutaneous inoculation.
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  • Yoichiro Kawaguchi
    1953 Volume 22 Issue 1 Pages 28-34
    Published: January 20, 1953
    Released on J-STAGE: December 10, 2008
    JOURNAL FREE ACCESS
    1) All samples of P. O. E. Sorbitan laurate (yucicogen 200) inhibited the growth of tubercle bacilli when added to Kirchner's media in concentrations of 0.1 percent or more.
    2) P. O. E. Sorbitan stearate (yucicogen 600) favored diffuse growth of tubercle bacilli in Kirchner's media.
    3) The other samples (yucicogen 800, yucicogen 60 yucicogen 610) had no ability to disperse cultures of tubercle bacilli.
    4) Enhancement of growth of tubercle bacilli was obtained when added to the media in concentration of 0.001 percent.
    5) Cultures growing diffusely in media consisted of cells of classical morphology and staining properties which again exhibited the usual made of growth when returned to the standard media.
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  • Shigenobu Kobayashi
    1953 Volume 22 Issue 1 Pages 35-38
    Published: January 20, 1953
    Released on J-STAGE: June 30, 2008
    JOURNAL FREE ACCESS
    The number of lepers affected by the perforating ulcer amount to 217 cases (21.57%) in 1006 lepers, as to the type: 0 (0%) in 60 macula types, 75 (27.57%) in 272 nervous types and 142 (21.07%) in 674 nodular types.
    The perforating ulcer occurs mostly in moderate stage and serious stage of leprosy.
    The lesions of predilection of the perforating ulcer are toe, foot-sole, hand, ankle, instep and leg.
    The disease is more frequent in males than females, and more frequent in right side than in left.
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  • Shigenobu Kobayashi
    1953 Volume 22 Issue 1 Pages 39-42
    Published: January 20, 1953
    Released on J-STAGE: June 30, 2008
    JOURNAL FREE ACCESS
    The following facts are necessary to discern regarding to the differentiation between the leprous perforating ulcer and that of other neural diseases.
    The clinical change of the extremeties affected by the perforating ulcer is following: The loss of hair is prominent or a little, anasthesia is observed on the skin of the palm and foot-sole, where the perspiration is surspended, and nerve of the forarm and leg is thickened.
    Lepra bacilli were proved in granulation and sequestrum of the perforating ulcer in 1 (5%) of 20 nervous types, and 15 (34.10 %) of 44 noduler types.
    There are almost same leprous changes in the histo-pathological view of the granulation of the perforating ulcer in nodular type.
    The perforating ulcer is not found in early stage of leprosy, and the disease does not almost take place in any case of beginning leprosy.
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  • Fujio Shimizu
    1953 Volume 22 Issue 1 Pages 43-44_1
    Published: January 20, 1953
    Released on J-STAGE: December 10, 2008
    JOURNAL FREE ACCESS
    The Fluorescent Microscopical Apparatus (Yasaki) easily revealed many lepra bacilli in the 18-20 year old materials of lepra nodosa (60 cases) and lepra nervosa (5 cases) of the nervus ulnaris. The Ziehl-Neelsen method was of less use here. The histological picture, in general, showed plenty of lepra bacilli in the young leprose granulation where the lepra cells were abundant. Where fibrosis was strong, there were fewer bacilli. There were not many in the round cell infiltration foci.
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  • [in Japanese]
    1953 Volume 22 Issue 1 Pages 45-47
    Published: January 20, 1953
    Released on J-STAGE: December 10, 2008
    JOURNAL FREE ACCESS
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