Soft Interfaces of Giant Vesicles Studied by Atomic Force Microscopy and Computer Simulations

Abstract

We have successfully immobilized a single giant vesicle onto the chemically modified surface of a cantilever for atomic force microscopy (AFM). The giant-vesicle-immobilized probes allowed us to measure the surface forces between soft interfaces. Additionally, we have carried out the simulations of the corresponding systems using the computational micro-fluid dynamics to reproduce successfully the force-distance curves, which were in qualitative agreement with those from the AFM measurements.