This review covers our studies about fully implantable sensor using glucose responsive fluorescence hydrogel based on our previous publications. We succeeded to fabricate the fluorescence hydrogel micro-beads and micro-fibers that have capability to be implanted to the ear of a mouse. Implanted fluorescence hydrogel sensors tracked the fluctuation of blood glucose concentration in the in vivo tests, and the glucose traceability has maintained until 140 days from the implantation with micro-fibers. PEG-bonded micro-fibers successfully suppressed the inflammation. The fluorescence measurement system has the great potential to realize the minimally-invasive and long-term implantable continuous glucose monitoring.
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