電気学会論文誌E(センサ・マイクロマシン部門誌)
Online ISSN : 1347-5525
Print ISSN : 1341-8939
ISSN-L : 1341-8939
特集論文
グルコースにて作動する減圧機構と化学駆動・制御による人工すい臓モデルに関するレビュー
三林 浩二
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ジャーナル フリー

2013 年 133 巻 10 号 p. 292-296

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抄録
Glucose-driven decompression device which utilizes conversion of chemical energy (glucose) to mechanical energy (actual pressure) has been developed and applied for a novel chemical controlled artificial pancreas system. The artificial system does not need to require any other power source such as electrical or mechanical energy. Integrated intermittent drug release actions and pressure changes were observed in record with CCD camera. The system was then evaluated in closed loop system setting for feedback control of the glucose concentration. The data revealed that drug release interval was extended causing stabilized constant glucose concentration on feedback effect. Accordingly, glucose concentration can be controlled autonomously similar with natural pattern of interdependent relationship between pancreas insulin secretion and glucose level. Potential applications of the organic engine include intelligent actuators, DDS (drug delivery system) and artificial muscles using biological energies (sugar, acid, lipid, etc.) with a neglibly-small heat loss.
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© 2013 電気学会
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