高感度表面増強ラマン分光分析に向けたマイクロ流路内粒子凝集反応解析

抄録

This paper focuses on silver nanoparticles “dimer” with a molecular bridge for highly sensitive trace detection by Surface-Enhanced Raman Spectroscopy (SERS). We clarified Raman intensity was determined from a concentration of particle dimers in mixing of nanoparticle and molecule solutions by characterization of SERS with the experimental and the analytical studies. The particle dimer gives us higher enhancement factor of SERS intensity than the conventionally used larger cluster of nanoparticles. We proposed a multilayered mixing of nanoparticle and molecule solutions to achieve a higher concentration of the particle dimer in an entire laser spot of a portable Raman spectroscope.