Specific Metallization of Double-Stranded DNA Using Reducing Group-Labeled Intercalator

Abstract

We demonstrated that the DNA metallization technique using reducing group-labeled intercalator molecules permits dsDNA (double-stranded DNA) molecules to be specifically metallized while not permitting metallization of ssDNA (single-stranded DNA) molecules. First, dsDNA and ssDNA molecules were stretched on a mica surface using spin-coating technique, and metallization process was conducted. AFM observation showed that only dsDNA molecules were metallized, resulting in formation of nanowires with a diameter of about 11 nm. Secondly, dsDNA and ssDNA molecules were stretched and immobilized between two microelectrodes. Impedance analysis showed that the electrical conductivity of only dsDNA was drastically increased after the metallization process.