血管内皮細胞とポドサイトの共培養により構築した糸球体濾過障壁におけるイヌリンとアルブミンの透過性評価

抄録

Main function of glomerulus is to filter plasma and waste products from blood. The filtration function is known to be impaired and irreversibly damaged by a disease or a drug administration. Therefore, nephrotoxicity assessment is essential for a new drug development. However, conventional animal models for drug screening cannot appropriately assess toxicity of drugs to human glomerulus. In this study, we constructed a glomerulus-on-a-chip using human podocytes and evaluated the selectivity of inulin and albumin for filtration function.