抄録
The ectopic pacemaker formation by aconitine in the left superior vena cava proximal to the heart was studied in rabbit.
(1) Aconitine produced the automatic activities in the isolated strip of vena caval muscle.
(2) During the recovery from aconitine poisoning the action potentials with diastolic slow depolarization were recorded from the region of the left superior vena cava near the coronary sinus.
(3) In the in situ experiment, tachycardia was produced by the local application to the left superior vena cava near the coronary sinus.
(4) From the above-mentioned facts, it was suggested that aconitine induced the ectopic pacemaker in the left superior vena cava proximal to the heart and that the impulse from the ectopic focus spread not only to the periphery but also to the atrium.
