Biochemical and Histopathological Response to Chrysotile Ingestion in Guinea Pigs

抄録

A periodic study of biochemical and histopathological changes in the stomach of guinea pigs, was carried out at 6, 12 and 24 hrs after oral admini-stration of 500 mg of chrysotile dust. The gastric juice showed a significant increase in volume, free and total acidity and peptic activity. A marked reduction in mucin contents, most significantly at 12 hrs also occurred. Significant dissolution of nickel and a parallel rise in ATPase activity of gastric mucosa was also observed. Histopathologically mucosa' injury was evident at 12 hrs but regressed by 24 hrs. The changes in acidity of gastric juice and dissolution of nickel are discussed with reference to their role in gastric ulceration or carcinoma by ingested asbestos.