Industrial Health
Online ISSN : 1880-8026
Print ISSN : 0019-8366
Imbalance of Testosterone Level in Male Offspring of Rats Perinatally Exposed to Bisphenol A
Sumiko WATANABERui-Sheng WANGMuneyuki MIYAGAWAKenichi KOBAYASHIMegumi SUDASoichiro SEKIGUCHITakeshi HONMA
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2003 年 41 巻 4 号 p. 338-341

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The purpose of this study was to investigate whether exposure to bisphenol A (BPA) through the placenta and milk has any effect on the reproductive system in male offspring. Pregnant rats were treated with BPA at 0, 4, 40 and 400 mg/kg body weight, from gestation day 6 through lactation day 20 by gavage. Plasma testosterone concentrations in offspring at 9 weeks old were significantly high in BPA groups as compared with those of the control. At the age of 36 weeks the hormone concentrations showed an increase in a dose-dependent manner, although without statistical significance. Testosterone content in testes showed a similar tendency to that in plasma, though statistically insignificant. Little alteration in testes weight was seen in BPA-exposed offspring. There was no remarkable change in plasma concentrations of luteinizing hormone and follicle-stimulating hormone at 9 weeks old. The pathway of E2 (17β-estradiol) formation from testosterone seemed not to be affected by BPA. The results indicate that exposure to BPA during the perinatal period has a significant effect on testosterone homeostasis in male offspring of rats.

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© National Institute of Occupational Safety and Health
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