抄録
We recently identified angiopoietin-like protein ANGPTL2 as a key mediator of chronic inflammation and its-associated diseases, such as obesity-related metabolic syndrome, cardiovascular disease, and some autoimmune diseases. Inflammation is receiving much attention for the role it plays at different stages of cancer development, including carcinogenesis, tumor invasion, and metastasis. More recently, we demonstrated that ANGPTL2 functions in the pathogenesis of cancer development, particular in inflammatory carcinogenesis and tumor metastasis. In this review, we focus on ANGPTL2 and its-associated chronic inflammation in carcinogenesis and tumor metastasis and propose that ANGPTL2 could serve a molecular target to prevent and treat pathologies associated with cancer.
