Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Cardiovascular Diseases
Cardiomyopathy with Prominent Autophagic Degeneration, Accompanied by an Elevated Plasma Brain Natriuretic Peptide Level Despite the Lack of Overt Heart Failure
Mieko SAIJOGenzou TAKEMURAMasahiko KODAHideshi OKADAShusaku MIYATAYasushi OHNOMasanori KAWASAKIKunihiko TSUCHIYAKazuhiko NISHIGAKIShinya MINATOGUCHIKoshi GOTOHisayoshi FUJIWARA
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JOURNALS OPEN ACCESS

2004 Volume 43 Issue 8 Pages 700-703

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Abstract

A 75-year-old man without overt heart failure showed an abnormally high level of brain natriuretic peptide (BNP) in plasma: 600 pg/ml. The left ventricular endomyocardial biopsy revealed prominent vacuolar degeneration in the myocytes, most of which were positive for PAS stain and BNP immunoreaction. Ultrastructurally, degenerative changes of myocytes were marked, such as deposits of glycogen and lipofuscin granules in the cytoplasm, but the most prominent finding was giant vacuoles containing degraded mitochondria, glycogen granules, myofibrils, and myelin-like structures (autophagosomes). This case may belong to one of the unclassified cardiomyopathies characterized by prominent autophagic vacuoles.

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© 2004 by The Japanese Society of Internal Medicine
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