A Case of Membranous Nephropathy with Primary Biliary Cirrhosis and Cyclosporine-induced Remission

Yusuke Sakamaki; Matsuhiko Hayashi; Shu Wakino; Seiichi Fukuda; Kounosuke Konishi; Akinori Hashiguchi; Koichi Hayashi; Hiroshi Itoh

doi:10.2169/internalmedicine.50.4020

CASE REPORTS

A Case of Membranous Nephropathy with Primary Biliary Cirrhosis and Cyclosporine-induced Remission

Yusuke Sakamaki, Matsuhiko Hayashi, Shu Wakino, Seiichi Fukuda, Kounosuke Konishi, Akinori Hashiguchi, Koichi Hayashi, Hiroshi Itoh

著者情報

キーワード: membranous nephropathy, primary biliary cirrhosis, nephrotic syndrome, cyclosporine

ジャーナルオープンアクセス

2011 年 50 巻 3 号 p. 233-238

DOI https://doi.org/10.2169/internalmedicine.50.4020

詳細

抄録

We report a case of membranous nephropathy with primary biliary cirrhosis (PBC). A 76-year-old Japanese man had been treated for PBC and was referred to our department because of acute severe proteinuria (10 g/day). Renal biopsy was performed and was compatible with a diagnosis of membranous nephropathy. The patient was treated with cyclosporine A (CsA; Neoral^®), which was followed by normalization of liver function and partial remission of proteinuria (0.68 g/day) within six months without any significant side effects. This case suggests that CsA monotherapy is effective for the treatment of both liver dysfunction and membranous nephropathy associated with PBC.

責任著者(Corresponding author)

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