Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Do Alpha-glucosidase Inhibitors Have the Potential to Induce Portal Venous Gas? -Two Clinical Case Reports
Hiroaki MakiyamaRyoko KataokaMasaru TauchiHiroki SumitomoRikiya Fuita
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ジャーナル オープンアクセス

2014 年 53 巻 7 号 p. 691-694

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抄録
We herein report two cases of portal venous gas (PVG) following alpha-glucosidase inhibitor (α-GI) therapy for diabetes mellitus. Anti-diabetic treatment with voglibose was commenced in the first case, while the second case was treated with miglitol. Both patients recovered without intensive treatment after discontinuing the α-GI therapy. α-GI medications may increase internal intestinal tract pressure by releasing carbon dioxide and hydrogen gas, potentially causing pneumatosis cystoides intestinalis (PCI) or PVG. Our experience suggests that α-GI therapy is an important potential cause of portal venous gas that can be treated conservatively.
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© 2014 by The Japanese Society of Internal Medicine
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