Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Vasculitic Neuropathy Following Exposure to a Glyphosate-based Herbicide
Yuichi KawagashiraHaruki KoikeKazuya KawabataMie TakahashiKen OhyamaRina HashimotoMasahiro IijimaMasahisa KatsunoGen Sobue
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JOURNALS OPEN ACCESS

2017 Volume 56 Issue 11 Pages 1431-1434

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Abstract

We herein report a case of peripheral neuropathy following exposure to large amounts of glyphosate-based herbicide. A 70-year-old man suffered from pain and purpura in the left sole following exposure to glyphosate-based herbicide. Pain and purpura spread to the opposite side and increased in severity. Mild weakness of the lower limbs was also observed. A sural nerve biopsy revealed the infiltration of lymphocytes around small vessels in the epineurium with numerous eosinophils, deposition of hemosiderins and focal axonal degeneration, compatible with findings of vasculitic neuropathy. Glyphosate-based herbicides should be recognized as a causative agent of vasculitic neuropathy.

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© 2017 by The Japanese Society of Internal Medicine
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