Primary CD30-positive Diffuse Large B-cell Lymphoma in the Superior Vena Cava

Shingen Nakamura; Kumiko Kagawa; Ryohei Sumitani; Munenori Uemura; Mamiko Takahashi; Masami Iwasa; Shiro Fujii; Hirokazu Miki; Masahiro Abe

doi:10.2169/internalmedicine.56.8203

CASE REPORTS

Primary CD30-positive Diffuse Large B-cell Lymphoma in the Superior Vena Cava

Shingen Nakamura, Kumiko Kagawa, Ryohei Sumitani, Munenori Uemura, Mamiko Takahashi, Masami Iwasa, Shiro Fujii, Hirokazu Miki, Masahiro Abe

著者情報

Shingen Nakamura
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan
Kumiko Kagawa
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan
Ryohei Sumitani
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan
Munenori Uemura
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan
Mamiko Takahashi
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan
Masami Iwasa
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan
Shiro Fujii
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan
Hirokazu Miki
Division of Transfusion Medicine and Cell Therapy, Tokushima University Hospital, Japan
Masahiro Abe
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan

キーワード: superior vena cava syndrome, malignant lymphoma, CD30, intravascular lymphoma

ジャーナルオープンアクセス

2017 年 56 巻 15 号 p. 2043-2047

DOI https://doi.org/10.2169/internalmedicine.56.8203

詳細

抄録

Primary superior vena cava lymphoma originating from the endothelium of a large vein is very rare. A 70-year-old man was admitted to the hospital; computed tomography showed a tumor limited to the inside of the superior vena cava, completely occluding the vessel. A transjugular biopsy confirmed the diagnosis of diffuse large B-cell lymphoma, which was diffusely positive for CD30. Rituximab monotherapy followed by five courses of R-CHOP chemotherapy induced a complete remission. There was no recurrence after two years. The pathophysiology of lymphoma derived from large vessels may be different from intravascular large B-cell lymphoma, which usually involves small vessels.

責任著者(Corresponding author)

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