Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Successful Treatment of Rapidly Progressive Unclassifiable Idiopathic Interstitial Pneumonia with Anti-melanoma Differentiation-associated Gene-5 Antibody by Intensive Immunosuppressive Therapy
Takuma KogaShinjiro KaiedaMasaki OkamotoKen MasudaKyoko FujimotoSatoshi SakamotoMasayuki NakamuraMasaki TominagaTomotaka KawayamaKiminori FujimotoTomoaki HoshinoHiroaki Ida
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JOURNALS OPEN ACCESS

2018 Volume 57 Issue 7 Pages 1039-1043

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Abstract

We describe a case of a woman who presented with a persistent cough, general fatigue, and a fever. Interstitial lung disease was rapidly progressive and resistant to high-dose steroid therapy. She tested positive for the presence of anti-melanoma differentiation-associated gene 5 (MDA-5) antibody, although she had no skin manifestations of dermatomyositis. She was eventually diagnosed with unclassifiable idiopathic interstitial pneumonia and was successfully treated with intensive immunosuppressive therapy including intravenous cyclophosphamide. To our knowledge, this is the first report of anti-MDA-5 antibody in a patient with idiopathic interstitial pneumonia.

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© 2018 by The Japanese Society of Internal Medicine
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